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Chemical structure of CBP/p300-IN-10

GC68841

CBP/p300-IN-10

Also known as (2R,4R)-1-[1-[4-(difluoromethoxy)phenyl]-4,4-difluorocyclohexanecarbonyl]-4-fluoro-N-(1H-pyrazolo[4,5-b]pyridin-5-yl)pyrrolidine-2-carboxamide

CBP/p300-IN-10 is an efficient inhibitor of histone acetyltransferases EP300 and CREBBP, with IC50 values of 26 nM and 39 nM, respectively

ChemicalCAS2259641-71-7MW537.48FormulaC25H24F5N5O3
CAS number
2259641-71-7
Molecular weight
537.48
Formula
C25H24F5N5O3
Solubility
DMSO ： 10·5 mg/mL (19·54 mM; ultrasonic and warming and heat to 80°C)
InChIKey
IGBIPTRCWSVZCO-DNVCBOLYSA-N
Catalogue number
GC68841
Brand
GLPBIO
Computed properties PubChem CID 142504196 · XLogP 4.4 · TPSA 100 Ų · H-bond donors 2
XLogP
4.4
TPSA
100 Ų
H-bond donors
2
H-bond acceptors
10
Rotatable bonds
6
Heavy atoms
38

SMILES C1CC(CCC1(C2=CC=C(C=C2)OC(F)F)C(=O)N3C[C@@H](C[C@@H]3C(=O)NC4=NC5=C(C=C4)NN=C5)F)(F)F

Computed descriptors from PubChem (CID 142504196), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
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Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
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