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Chemical structure of CBP/p300-IN-12

GC64696

CBP/p300-IN-12

Also known as N-[3-[[(5R)-3-[2-[(4-fluorophenyl)methyl-[(2S)-1,1,1-trifluoropropan-2-yl]amino]-2-oxoethyl]-2,4-dioxospiro[1,3-oxazolidine-5,1'-2,3-dihydroindene]-5'-yl]carbamoylamino]phenyl]prop-2-enamide

CBP/p300-IN-12 is a potent and selective covalent histone acetyltransferases p300 (IC50 of 166 nM) and CBP inhibitor· CBP/p300-IN-12 decreases the levels of H3K27Ac of PC-3 cells (EC50 of 37 nM)· CBP/p300-IN-12 forms a covalent adduct with C1450

ChemicalCAS2738688-57-6MW667.61FormulaC33H29F4N5O6
CAS number
2738688-57-6
Molecular weight
667.61
Formula
C33H29F4N5O6
Solubility
DMSO ： 250 mg/mL (374·47 mM; Need ultrasonic)
InChIKey
JUWRXRFZRKHMBP-PSTIOWGYSA-N
Catalogue number
GC64696
Brand
GLPBIO
Computed properties PubChem CID 162640854 · XLogP 4.6 · TPSA 137 Ų · H-bond donors 3
XLogP
4.6
TPSA
137 Ų
H-bond donors
3
H-bond acceptors
10
Rotatable bonds
9
Heavy atoms
48

SMILES C[C@@H](C(F)(F)F)N(CC1=CC=C(C=C1)F)C(=O)CN2C(=O)[C@]3(CCC4=C3C=CC(=C4)NC(=O)NC5=CC=CC(=C5)NC(=O)C=C)OC2=O

Computed descriptors from PubChem (CID 162640854), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
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Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
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Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.