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Chemical structure of BLU2864

GC68776

BLU2864

Also known as N-[(1R,2S)-5-(difluoromethyl)-7-fluoro-2-hydroxy-2,3-dihydro-1H-inden-1-yl]-6-(3-methyl-1H-pyrrolo[2,3-b]pyridin-4-yl)pyridine-3-carboxamide

BLU2864 is an orally active, highly selective, ATP-competitive inhibitor of PRKACA (IC50=0·3 nM)· BLU2864 has anti-tumor activity and can be used for research on cancer and polycystic kidney disease

ChemicalCAS2810747-89-6MW452.43FormulaC24H19F3N4O2
CAS number
2810747-89-6
Molecular weight
452.43
Formula
C24H19F3N4O2
Solubility
DMSO ： 100 mg/mL (221·03 mM; Need ultrasonic)
InChIKey
VRPOVDLLZCQZEG-RXVVDRJESA-N
Catalogue number
GC68776
Brand
GLPBIO
Computed properties PubChem CID 164603354 · XLogP 3.2 · TPSA 90.9 Ų · H-bond donors 3
XLogP
3.2
TPSA
90.9 Ų
H-bond donors
3
H-bond acceptors
7
Rotatable bonds
4
Heavy atoms
33

SMILES CC1=CNC2=NC=CC(=C12)C3=NC=C(C=C3)C(=O)N[C@H]4[C@H](CC5=C4C(=CC(=C5)C(F)F)F)O

Computed descriptors from PubChem (CID 164603354), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
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Documents
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