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Chemical structure of BLU-554

GC19075

BLU-554

Also known as N-[(3S,4S)-3-[[6-(2,6-dichloro-3,5-dimethoxyphenyl)quinazolin-2-yl]amino]oxan-4-yl]prop-2-enamide

BLU-554 (BLU-554) is a potent, highly selective and orally active fibroblast growth factor receptor 4 (FGFR4) inhibitor with an IC50 of 5 nM· BLU-554 has significant anti-tumor activity in models of hepatocellular carcinoma (HCC) that are dependent on FGFR4 signalling

ChemicalCAS1707289-21-1MW503.38FormulaC24H24Cl2N4O4
CAS number
1707289-21-1
Molecular weight
503.38
Formula
C24H24Cl2N4O4
Solubility
DMSO ： ≥ 25 mg/mL (49·66 mM)
InChIKey
MGZKYOAQVGSSGC-DLBZAZTESA-N
Catalogue number
GC19075
Brand
GLPBIO
Computed properties PubChem CID 91885617 · XLogP 4.7 · TPSA 94.6 Ų · H-bond donors 2
XLogP
4.7
TPSA
94.6 Ų
H-bond donors
2
H-bond acceptors
7
Rotatable bonds
7
Heavy atoms
34

SMILES COC1=CC(=C(C(=C1Cl)C2=CC3=CN=C(N=C3C=C2)N[C@@H]4COCC[C@@H]4NC(=O)C=C)Cl)OC

Computed descriptors from PubChem (CID 91885617), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
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Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
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