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Chemical structure of BI-1622

GC68759

BI-1622

Also known as 1-[4-[4-[3-methyl-4-([1,2,4]triazolo[1,5-a]pyridin-7-yloxy)anilino]pyrimido[5,4-d]pyrimidin-6-yl]piperazin-1-yl]prop-2-en-1-one

BI-1622 is an orally effective and highly selective HER2 (ERBB2) inhibitor with an IC50 of 7 nM· BI-1622 has a selectivity for EGFR greater than 25-fold· In transplant mouse models of H2170 and PC9 cells, BI-1622 showed high in vivo anti-tumor effects and has good activity molecular metabolism and pharmacokinetic properties

ChemicalCAS2681392-19-6MW508.53FormulaC26H24N10O2
CAS number
2681392-19-6
Molecular weight
508.53
Formula
C26H24N10O2
Solubility
DMSO ： 100 mg/mL (196·65 mM; Need ultrasonic)
InChIKey
KXUBSQUYDKKQTR-UHFFFAOYSA-N
Catalogue number
GC68759
Brand
GLPBIO
Computed properties PubChem CID 156821237 · XLogP 2.8 · TPSA 127 Ų · H-bond donors 1
XLogP
2.8
TPSA
127 Ų
H-bond donors
1
H-bond acceptors
10
Rotatable bonds
6
Heavy atoms
38

SMILES CC1=C(C=CC(=C1)NC2=NC=NC3=CN=C(N=C32)N4CCN(CC4)C(=O)C=C)OC5=CC6=NC=NN6C=C5

Computed descriptors from PubChem (CID 156821237), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
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Pricing
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Documents
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