Loading...
Chemical structure of AD57

GC68623

AD57

Also known as 1-[4-(4-amino-1-propan-2-ylpyrazolo[3,4-d]pyrimidin-3-yl)phenyl]-3-[3-(trifluoromethyl)phenyl]urea

AD57 is a type of orally active multi-kinase inhibitor that inhibits the activity of RET, BRAF, S6K and Src, but has significantly reduced activity against mTOR

ChemicalCAS1093380-42-7MW455.44FormulaC22H20F3N7O
CAS number
1093380-42-7
Molecular weight
455.44
Formula
C22H20F3N7O
Solubility
DMSO ： 125 mg/mL (274·46 mM; Need ultrasonic)
InChIKey
LEERPLGXOHLQPF-UHFFFAOYSA-N
Catalogue number
GC68623
Brand
GLPBIO
Computed properties PubChem CID 25011745 · XLogP 3.6 · TPSA 111 Ų · H-bond donors 3
XLogP
3.6
TPSA
111 Ų
H-bond donors
3
H-bond acceptors
8
Rotatable bonds
4
Heavy atoms
33

SMILES CC(C)N1C2=NC=NC(=C2C(=N1)C3=CC=C(C=C3)NC(=O)NC4=CC=CC(=C4)C(F)(F)F)N

Computed descriptors from PubChem (CID 25011745), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.