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Chemical structure of ACT-660602

GC68619

ACT-660602

Also known as 2-(3,5-dimethyl-1,2,4-triazol-1-yl)-1-[(2R)-2-methyl-4-[2-(trifluoromethyl)-4-[2-(trifluoromethyl)pyrimidin-5-yl]-1,3-thiazol-5-yl]piperazin-1-yl]ethanone

ACT-660602 is an orally active antagonist of the chemokine receptor CXCR3 with an IC50 of 204 nM· It inhibits T cell migration and exhibits significant effects in an acute lung injury model in vivo· ACT-660602 can be used for research on autoimmune diseases

ChemicalCAS1646267-59-5MW534.48FormulaC20H20F6N8OS
CAS number
1646267-59-5
Molecular weight
534.48
Formula
C20H20F6N8OS
Solubility
DMSO ： 110 mg/mL (205·81 mM; Need ultrasonic)
InChIKey
JENUMEXEVAAAJX-SNVBAGLBSA-N
Catalogue number
GC68619
Brand
GLPBIO
Computed properties PubChem CID 87056189 · XLogP 3.6 · TPSA 121 Ų · H-bond donors 0
XLogP
3.6
TPSA
121 Ų
H-bond donors
0
H-bond acceptors
14
Rotatable bonds
4
Heavy atoms
36

SMILES C[C@@H]1CN(CCN1C(=O)CN2C(=NC(=N2)C)C)C3=C(N=C(S3)C(F)(F)F)C4=CN=C(N=C4)C(F)(F)F

Computed descriptors from PubChem (CID 87056189), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
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Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.