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Chemical structure of BRD4/CK2-IN-1

GC66441

BRD4/CK2-IN-1

Also known as N-[3-chloro-4-(4-methylpiperazin-1-yl)phenyl]-2-[4-(5,7-dimethoxy-4-oxo-3H-quinazolin-2-yl)phenoxy]acetamide

BRD4/CK2-IN-1 is the first highly effective and oral active dual-target inhibitor of BRD4/CK2 (bromodomain-containing protein 4/casein kinase 2), with IC50s of 180 nM and 230 nM for BRD4 and CK2, respectively· BRD4/CK2-IN-1 has strong anticancer activity without obvious toxicities· BRD4/CK2-IN-1 induces apoptosis and autophagy-associated cell death in triple-negative breast cancer (TNBC)

ChemicalCAS2756851-99-5MW564.03FormulaC29H30ClN5O5
CAS number
2756851-99-5
Molecular weight
564.03
Formula
C29H30ClN5O5
Solubility
DMSO ： 20 mg/mL (35·46 mM; ultrasonic and warming and adjust pH to 3 with HCl and heat to 60°C)
InChIKey
UZWCUBDJHDWTFV-UHFFFAOYSA-N
Catalogue number
GC66441
Brand
GLPBIO
Computed properties PubChem CID 162641712 · XLogP 3.7 · TPSA 105 Ų · H-bond donors 2
XLogP
3.7
TPSA
105 Ų
H-bond donors
2
H-bond acceptors
8
Rotatable bonds
8
Heavy atoms
40

SMILES CN1CCN(CC1)C2=C(C=C(C=C2)NC(=O)COC3=CC=C(C=C3)C4=NC5=C(C(=CC(=C5)OC)OC)C(=O)N4)Cl

Computed descriptors from PubChem (CID 162641712), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.