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Chemical structure of WEE1-IN-5

GC65994

WEE1-IN-5

Also known as 6-(2,6-dichlorophenyl)-8-methyl-2-[3-methyl-4-(1-methylpiperidin-4-yl)anilino]-7H-pyrimido[4,5-d]pyrimidin-5-one

WEE1-IN-5 is a potent WEE1 inhibitor with an IC50 value of 0·8 nM· WEE1-IN-5 inhibits phospho-CDC2· WEE1-IN-5 abrogates the G2 check point, increasing sensitivity to DNA damaging agents in cancer cells· WEE1-IN-5 can be used for researching anticancer

ChemicalCAS2243882-74-6MW511.45FormulaC26H28Cl2N6O
CAS number
2243882-74-6
Molecular weight
511.45
Formula
C26H28Cl2N6O
Solubility
DMSO ： 125 mg/mL (244·40 mM; Need ultrasonic)
InChIKey
VWHNEYAANMETIA-UHFFFAOYSA-N
Catalogue number
GC65994
Brand
GLPBIO
Computed properties PubChem CID 152206257 · XLogP 5.6 · TPSA 64.6 Ų · H-bond donors 1
XLogP
5.6
TPSA
64.6 Ų
H-bond donors
1
H-bond acceptors
6
Rotatable bonds
4
Heavy atoms
35

SMILES CC1=C(C=CC(=C1)NC2=NC=C3C(=N2)N(CN(C3=O)C4=C(C=CC=C4Cl)Cl)C)C5CCN(CC5)C

Computed descriptors from PubChem (CID 152206257), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
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