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Chemical structure of P53R3

GC65961

P53R3

Also known as methyl (2S)-2-[[2-[[4-[bis(4-chlorophenyl)methyl]piperazin-1-yl]methyl]quinazolin-4-yl]amino]-3-methylbutanoate

P53R3 is a potent p53 reactivator and restores sequence-specific DNA binding of p53 hot spot mutants, including p53R175H, p53R248W and p53R273H· P53R3 induces p53-dependent antiproliferative effects with much higher specificity than PRIMA-1· P53R3 enhances the recruitment of wild-type p53 and p53M237I to several target gene promoters· P53R3 strongly enhances the mRNA, total protein and cell surface expression of the death receptor death receptor 5 (DR5)· P53R3 is used for cancer research

ChemicalCAS922150-12-7MW592.56FormulaC32H35Cl2N5O2
CAS number
922150-12-7
Molecular weight
592.56
Formula
C32H35Cl2N5O2
Solubility
DMSO ： ≥ 100 mg/mL (168·76 mM)
InChIKey
DFBRKGUTHGRQMH-LJAQVGFWSA-N
Catalogue number
GC65961
Brand
GLPBIO
Computed properties PubChem CID 58809185 · XLogP 7.3 · TPSA 70.6 Ų · H-bond donors 1
XLogP
7.3
TPSA
70.6 Ų
H-bond donors
1
H-bond acceptors
7
Rotatable bonds
10
Heavy atoms
41

SMILES CC(C)[C@@H](C(=O)OC)NC1=NC(=NC2=CC=CC=C21)CN3CCN(CC3)C(C4=CC=C(C=C4)Cl)C5=CC=C(C=C5)Cl

Computed descriptors from PubChem (CID 58809185), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.