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Chemical structure of MS170

GC65466

MS170

Also known as 3-[[(2S)-2-(4-chlorophenyl)-3-[4-[(5R,7R)-7-hydroxy-5-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl]piperazin-1-yl]-3-oxopropyl]amino]-N-[8-[[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]amino]octyl]propanamide

MS170 is a potent and selective PROTAC AKT degrader· MS170 depletes cellular total AKT (T-AKT) with the DC50 value of 32 nM· MS170 binds to AKT1, AKT2, and AKT3 with Kds of 1·3 nM, 77 nM, and 6·5 nM, respectively

ChemicalCAS2376136-61-5MW870.44FormulaC45H56ClN9O7
CAS number
2376136-61-5
Molecular weight
870.44
Formula
C45H56ClN9O7
InChIKey
QMLFGZYEQAMKRK-SCQVZNLVSA-N
Catalogue number
GC65466
Brand
GLPBIO
Computed properties PubChem CID 155410759 · XLogP 3.9 · TPSA 206 Ų · H-bond donors 5
XLogP
3.9
TPSA
206 Ų
H-bond donors
5
H-bond acceptors
12
Rotatable bonds
19
Heavy atoms
62

SMILES C[C@@H]1C[C@H](C2=C1C(=NC=N2)N3CCN(CC3)C(=O)[C@H](CNCCC(=O)NCCCCCCCCNC4=CC=CC5=C4C(=O)N(C5=O)C6CCC(=O)NC6=O)C7=CC=C(C=C7)Cl)O

Computed descriptors from PubChem (CID 155410759), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.