GC39407
MS1943
Also known as 6-[6-[4-[2-[[2-(1-adamantyl)acetyl]amino]ethyl]piperazin-1-yl]-3-pyridinyl]-N-[(4,6-dimethyl-2-oxo-1H-pyridin-3-yl)methyl]-1-propan-2-ylindazole-4-carboxamide
MS1943 is a first-in-class, orally bioavailable EZH2 selective degrader, with an IC50 of 120 nM· MS1943 significantly reduces EZH2 protein levels in numerous triple-negative breast cancer (TNBC) and other cancer and noncancerous cell lines· MS1943 effectively blocks proliferation of multiple TNBC and other cancer cell lines
- CAS number
- 2225938-17-8
- Molecular weight
- 718.93
- Formula
- C42H54N8O3
- Solubility
- DMSO： 125 mg/mL (173·87 mM)
- InChIKey
- WQIQJFXBAJJKNT-UHFFFAOYSA-N
- Catalogue number
- GC39407
- Brand
- GLPBIO
Computed properties PubChem CID 139211327 · XLogP 5.7 · TPSA 124 Ų · H-bond donors 3
- XLogP
- 5.7
- TPSA
- 124 Ų
- H-bond donors
- 3
- H-bond acceptors
- 7
- Rotatable bonds
- 11
- Heavy atoms
- 53
SMILES CC1=CC(=C(C(=O)N1)CNC(=O)C2=C3C=NN(C3=CC(=C2)C4=CN=C(C=C4)N5CCN(CC5)CCNC(=O)CC67CC8CC(C6)CC(C8)C7)C(C)C)C
Computed descriptors from PubChem (CID 139211327), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.
Ordering in Israel
- Lead time
- Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
- Pricing
- Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
- Documents
- Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
- Who we serve
- Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.
- Questions
- WhatsApp · +972-55-990-7576 · orders@labo.co.il