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Chemical structure of MS154

GC75264

MS154

Also known as 3-[4-[3-[4-(3-chloro-4-fluoroanilino)-7-methoxyquinazolin-6-yl]oxypropyl]piperazin-1-yl]-N-[8-[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]oxyoctyl]propanamide

MS154 is a first-in-class E3 ligase cereblon-recruiting EGFR degrader with Kds of 1·8 nM and 3·8 nM for EGFR WT and EGFR L858R mutants

ChemicalCAS2550393-21-8MW901.42FormulaC46H54ClFN8O8
CAS number
2550393-21-8
Molecular weight
901.42
Formula
C46H54ClFN8O8
Solubility
DMSO： 90·14 mg/mL (100·00 mM; Need ultrasonic and warming)
InChIKey
ALKKWBPMCDDKKA-UHFFFAOYSA-N
Catalogue number
GC75264
Brand
GLPBIO
Computed properties PubChem CID 145996534 · XLogP 5.9 · TPSA 185 Ų · H-bond donors 3
XLogP
5.9
TPSA
185 Ų
H-bond donors
3
H-bond acceptors
14
Rotatable bonds
22
Heavy atoms
64

SMILES COC1=C(C=C2C(=C1)N=CN=C2NC3=CC(=C(C=C3)F)Cl)OCCCN4CCN(CC4)CCC(=O)NCCCCCCCCOC5=CC=CC6=C5C(=O)N(C6=O)C7CCC(=O)NC7=O

Computed descriptors from PubChem (CID 145996534), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.