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Chemical structure of CDK7/12-IN-1

GC65434

CDK7/12-IN-1

Also known as (3R,4R)-4-[[[7-[(2,7-dimethylimidazo[1,2-a]pyridin-3-yl)methylamino]-3-propan-2-ylpyrazolo[1,5-a]pyrimidin-5-yl]amino]methyl]piperidin-3-ol

CDK7/12-IN-1 is a selective CDK7/12 inhibitor with IC50s of 3 and 277 nM for CDK7 and CDK 12, respectively· CDK7 and CDK12 inhibition is an effective strategy to inhibit tumour growth

ChemicalCAS2654075-94-0MW462.59FormulaC25H34N8O
CAS number
2654075-94-0
Molecular weight
462.59
Formula
C25H34N8O
Solubility
DMSO ： 100 mg/mL (216·17 mM; Need ultrasonic)
InChIKey
IHXKZRXUGKSPTO-NQIIRXRSSA-N
Catalogue number
GC65434
Brand
GLPBIO
Computed properties PubChem CID 156525415 · XLogP 3.6 · TPSA 104 Ų · H-bond donors 4
XLogP
3.6
TPSA
104 Ų
H-bond donors
4
H-bond acceptors
7
Rotatable bonds
7
Heavy atoms
34

SMILES CC1=CC2=NC(=C(N2C=C1)CNC3=CC(=NC4=C(C=NN34)C(C)C)NC[C@H]5CCNC[C@@H]5O)C

Computed descriptors from PubChem (CID 156525415), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.