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Chemical structure of CDK7-IN-3

GC62596

CDK7-IN-3

Also known as 7-dimethylphosphoryl-3-[2-[[(3S)-6,6-dimethylpiperidin-3-yl]amino]-5-(trifluoromethyl)pyrimidin-4-yl]-1H-indole-6-carbonitrile

CDK7-IN-3 (CDK7-IN-3) is an orally active, highly selective, noncovalent CDK7 inhibitor with a KD of 0·065 nM· CDK7-IN-3 shows poor inhibition on CDK2 (Ki=2600 nM), CDK9 (Ki=960 nM), CDK12 (Ki=870 nM)· CDK7-IN-3 induces apoptosis in tumor cells and has antitumor activity

ChemicalCAS2417302-07-7MW490.46FormulaC23H26F3N6OP
CAS number
2417302-07-7
Molecular weight
490.46
Formula
C23H26F3N6OP
Solubility
DMSO ： 40 mg/mL (81·56 mM; Need ultrasonic)
InChIKey
JDJOUBVVSQDIRC-AWEZNQCLSA-N
Catalogue number
GC62596
Brand
GLPBIO
Computed properties PubChem CID 146662729 · XLogP 2.7 · TPSA 106 Ų · H-bond donors 3
XLogP
2.7
TPSA
106 Ų
H-bond donors
3
H-bond acceptors
9
Rotatable bonds
4
Heavy atoms
34

SMILES CC1(CC[C@@H](CN1)NC2=NC=C(C(=N2)C3=CNC4=C3C=CC(=C4P(=O)(C)C)C#N)C(F)(F)F)C

Computed descriptors from PubChem (CID 146662729), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.