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Chemical structure of CDK7-IN-2

GC63980

CDK7-IN-2

Also known as [(3S)-1-[(E)-4-(dimethylamino)but-2-enoyl]pyrrolidin-3-yl] 4-[(5-methyl-3-propan-2-ylpyrazolo[1,5-a]pyrimidin-7-yl)amino]piperidine-1-carboxylate

CDK7-IN-2 is a potent inhibitor of CDK7· CDK7 is implicated in both temporal control of the cell cycle and transcriptional activity· CDK7 is implicated in the transcriptional initiation process by phosphorylation of Rbpl subunit of RNA Polymerase II (RNAPII)· CDK7 has the potential for the research of cancer disease, in particular aggressive and hard- to-treat cancers (extracted from patent WO2019099298A1, compound 1)

ChemicalCAS2326428-19-5MW497.63FormulaC26H39N7O3
CAS number
2326428-19-5
Molecular weight
497.63
Formula
C26H39N7O3
Solubility
DMSO ： 100 mg/mL (200·95 mM; Need ultrasonic)
InChIKey
GRDAHPJRLCTJNA-BXKJMJEDSA-N
Catalogue number
GC63980
Brand
GLPBIO
Computed properties PubChem CID 138608760 · XLogP 2.6 · TPSA 95.3 Ų · H-bond donors 1
XLogP
2.6
TPSA
95.3 Ų
H-bond donors
1
H-bond acceptors
7
Rotatable bonds
8
Heavy atoms
36

SMILES CC1=NC2=C(C=NN2C(=C1)NC3CCN(CC3)C(=O)O[C@H]4CCN(C4)C(=O)/C=C/CN(C)C)C(C)C

Computed descriptors from PubChem (CID 138608760), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.