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Chemical structure of PTC299

GC65335

PTC299

Also known as (4-chlorophenyl) 6-chloro-1-(4-methoxyphenyl)-1,3,4,9-tetrahydropyrido[3,4-b]indole-2-carboxylate

PTC299 is an orally active inhibitor of VEGFA mRNA translation that selectively inhibits VEGF protein synthesis at the post-transcriptional level· PTC299 is also a potent inhibitor of dihydroorotate dehydrogenase (DHODH)· PTC299 shows good oral bioavailability and lack of off-target kinase inhibition and myelosuppression· PTC299 can be useful for the research of hematologic malignancies

ChemicalCAS1256565-36-2MW467.34FormulaC25H20Cl2N2O3
CAS number
1256565-36-2
Molecular weight
467.34
Formula
C25H20Cl2N2O3
Solubility
DMSO ： 50 mg/mL (106·99 mM; Need ultrasonic)
InChIKey
SRSHBZRURUNOSM-UHFFFAOYSA-N
Catalogue number
GC65335
Brand
GLPBIO
Computed properties PubChem CID 11190538 · XLogP 6.3 · TPSA 54.6 Ų · H-bond donors 1
XLogP
6.3
TPSA
54.6 Ų
H-bond donors
1
H-bond acceptors
3
Rotatable bonds
4
Heavy atoms
32

SMILES COC1=CC=C(C=C1)C2C3=C(CCN2C(=O)OC4=CC=C(C=C4)Cl)C5=C(N3)C=CC(=C5)Cl

Computed descriptors from PubChem (CID 11190538), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
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