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Chemical structure of PTC596

GC38592

PTC596

Also known as 5-fluoro-2-(6-fluoro-2-methylbenzimidazol-1-yl)-4-N-[4-(trifluoromethyl)phenyl]pyrimidine-4,6-diamine

PTC596 (PTC596) is an orally active and selective B-cell-specific Moloney murine leukemia virus integration site 1 (BMI-1) inhibitor· PTC596 downregulates MCL-1 and induces p53-independent mitochondrial apoptosis in acute myeloid leukemia (AML) cells· PTC596 has anti-leukemic activity

ChemicalCAS1610964-64-1MW420.34FormulaC19H13F5N6
CAS number
1610964-64-1
Molecular weight
420.34
Formula
C19H13F5N6
Solubility
DMF： 30 mg/ml,DMSO： 30 mg/ml,Ethanol： 5 mg/ml
InChIKey
TWLWOOPCEXYVBE-UHFFFAOYSA-N
Catalogue number
GC38592
Brand
GLPBIO
Computed properties PubChem CID 74223469 · XLogP 4.7 · TPSA 81.7 Ų · H-bond donors 2
XLogP
4.7
TPSA
81.7 Ų
H-bond donors
2
H-bond acceptors
10
Rotatable bonds
3
Heavy atoms
30

SMILES CC1=NC2=C(N1C3=NC(=C(C(=N3)NC4=CC=C(C=C4)C(F)(F)F)F)N)C=C(C=C2)F

Computed descriptors from PubChem (CID 74223469), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
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Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.