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Chemical structure of EW-7195

GC65329

EW-7195

Also known as 3-[[5-(6-methyl-2-pyridinyl)-4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-1H-imidazol-2-yl]methylamino]benzonitrile

EW-7195 is a potent and selective ALK5 (TGFβR1) inhibitor with an IC50 of 4·83 nM· EW-7195 has >300-fold selectivity for ALK5 over p38α· EW-7195 efficiently inhibits TGF-β1-induced Smad signaling, epithelial-to-mesenchymal transition (EMT) and breast tumour metastasis to the lung

ChemicalCAS1352609-28-9MW406.44FormulaC23H18N8
CAS number
1352609-28-9
Molecular weight
406.44
Formula
C23H18N8
Solubility
DMSO ： 50 mg/mL (123·02 mM; Need ultrasonic)
InChIKey
KEADGKSQIBFYEE-UHFFFAOYSA-N
Catalogue number
GC65329
Brand
GLPBIO
Computed properties PubChem CID 54767248 · XLogP 2.8 · TPSA 108 Ų · H-bond donors 2
XLogP
2.8
TPSA
108 Ų
H-bond donors
2
H-bond acceptors
6
Rotatable bonds
5
Heavy atoms
31

SMILES CC1=NC(=CC=C1)C2=C(N=C(N2)CNC3=CC=CC(=C3)C#N)C4=CN5C(=NC=N5)C=C4

Computed descriptors from PubChem (CID 54767248), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.