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Chemical structure of BI8622

GC65305

BI8622

Also known as N-[4-(aminomethyl)phenyl]-6-(4-cyano-4-phenylpiperidin-1-yl)-5-methylpyrimidine-4-carboxamide

BI8622 is a specific inhibitor of the ubiquitin ligase HUWE1 with an IC50 of 3·1 μM

ChemicalCAS1875036-74-0MW426.51FormulaC25H26N6O
CAS number
1875036-74-0
Molecular weight
426.51
Formula
C25H26N6O
Solubility
DMSO ： 125 mg/mL (293·08 mM; Need ultrasonic)
InChIKey
IJHAXMJRQQTBPL-UHFFFAOYSA-N
Catalogue number
GC65305
Brand
GLPBIO
Computed properties PubChem CID 138377590 · XLogP 2.7 · TPSA 108 Ų · H-bond donors 2
XLogP
2.7
TPSA
108 Ų
H-bond donors
2
H-bond acceptors
6
Rotatable bonds
5
Heavy atoms
32

SMILES CC1=C(N=CN=C1N2CCC(CC2)(C#N)C3=CC=CC=C3)C(=O)NC4=CC=C(C=C4)CN

Computed descriptors from PubChem (CID 138377590), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.