Loading...
Chemical structure of Volasertib

GC11224

Volasertib

Also listed as BI6727(Volasertib)

BI6727(Volasertib) (BI 6727) is an orally active, highly potent and ATP-competitive Polo-like kinase 1 (PLK1) inhibitor with an IC50 of 0·87 nM· BI6727(Volasertib) inhibits PLK2 and PLK3 with IC50s of 5 and 56 nM, respectively· BI6727(Volasertib) induces mitotic arrest and apoptosis· BI6727(Volasertib), a dihydropteridinone derivative, shows marked antitumor activity in multiple cancer models

ChemicalCAS755038-65-4MW618.83FormulaC34H50N8O3
CAS number
755038-65-4
Molecular weight
618.83
Formula
C34H50N8O3
Solubility
≥ 10·3mg/mL in DMSO
InChIKey
SXNJFOWDRLKDSF-XKHVUIRMSA-N
Catalogue number
GC11224
Brand
GLPBIO
Computed properties PubChem CID 10461508 · XLogP 4.6 · TPSA 106 Ų · H-bond donors 2
XLogP
4.6
TPSA
106 Ų
H-bond donors
2
H-bond acceptors
9
Rotatable bonds
10
Heavy atoms
45

SMILES CC[C@@H]1C(=O)N(C2=CN=C(N=C2N1C(C)C)NC3=C(C=C(C=C3)C(=O)NC4CCC(CC4)N5CCN(CC5)CC6CC6)OC)C

Computed descriptors from PubChem (CID 10461508), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.