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Chemical structure of MS4077

GC65243

MS4077

Also known as 2-[4-[4-[[5-chloro-4-(2-propan-2-ylsulfonylanilino)pyrimidin-2-yl]amino]-2-methyl-5-propan-2-yloxyphenyl]piperidin-1-yl]-N-[2-[2-[2-[2-[2-[2-[[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]amino]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethyl]acetamide

MS4077 is an anaplastic lymphoma kinase (ALK) PROTAC (degrader) based on Cereblon ligand, with a Kd of 37?nM for binding affinity to ALK

ChemicalCAS2230077-10-6MW1134.73FormulaC55H72ClN9O13S
CAS number
2230077-10-6
Molecular weight
1134.73
Formula
C55H72ClN9O13S
Solubility
DMSO ： 110 mg/mL (96·94 mM; Need ultrasonic)
InChIKey
VEKJQNCZEPLNJF-UHFFFAOYSA-N
Catalogue number
GC65243
Brand
GLPBIO
Computed properties PubChem CID 137628669 · XLogP 5.9 · TPSA 276 Ų · H-bond donors 5
XLogP
5.9
TPSA
276 Ų
H-bond donors
5
H-bond acceptors
19
Rotatable bonds
31
Heavy atoms
79

SMILES CC1=CC(=C(C=C1C2CCN(CC2)CC(=O)NCCOCCOCCOCCOCCOCCNC3=CC=CC4=C3C(=O)N(C4=O)C5CCC(=O)NC5=O)OC(C)C)NC6=NC=C(C(=N6)NC7=CC=CC=C7S(=O)(=O)C(C)C)Cl

Computed descriptors from PubChem (CID 137628669), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.