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Chemical structure of MKC-1

GC65143

MKC-1

Also known as 3-(1-methylindol-3-yl)-4-(1-methyl-6-nitroindol-3-yl)pyrrole-2,5-dione

MKC-1 (Ro-31-7453) is an orally active and potent cell cycle inhibitor with broad antitumor activity· MKC-1 inhibits the Akt/mTOR pathway· MKC-1 arrests cellular mitosis and induces cell apoptosis by binding to a number of different cellular proteins including tubulin and members of the importin β family

ChemicalCAS125313-92-0MW400.39FormulaC22H16N4O4
CAS number
125313-92-0
Molecular weight
400.39
Formula
C22H16N4O4
InChIKey
OVSKGTONMLKNPZ-UHFFFAOYSA-N
Catalogue number
GC65143
Brand
GLPBIO
Computed properties PubChem CID 5327686 · XLogP 2.6 · TPSA 102 Ų · H-bond donors 1
XLogP
2.6
TPSA
102 Ų
H-bond donors
1
H-bond acceptors
4
Rotatable bonds
2
Heavy atoms
30

SMILES CN1C=C(C2=CC=CC=C21)C3=C(C(=O)NC3=O)C4=CN(C5=C4C=CC(=C5)[N+](=O)[O-])C

Computed descriptors from PubChem (CID 5327686), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

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