GC32889
MKC8866 (IRE-1α inhibitor 1)
Also known as 7-hydroxy-6-methoxy-4-methyl-3-(2-morpholin-4-yl-2-oxoethyl)-2-oxochromene-8-carbaldehyde
MKC8866 (IRE-1α inhibitor 1), a salicylaldehyde analog, is a potent, selective IRE1 RNase inhibitor with an IC50 of 0·29μM in human vitro· MKC8866 (IRE-1α inhibitor 1) strongly inhibits Dithiothreitol-induced X-box-binding protein 1-spliced (XBP1s) expression with an EC50 of 0·52μM and unstresses RPMI 8226 cells with an IC50 of 0·14μM· MKC8866 (IRE-1α inhibitor 1) inhibits IRE1 RNase in breast cancer cells leading to the decreased production of pro-tumorigenic factors and it can inhibits prostate cancer (PCa) tumor growth
- CAS number
- 1338934-59-0
- Molecular weight
- 361.35
- Formula
- C18H19NO7
- Solubility
- DMSO ： 16·67 mg/mL (46·13 mM)
- InChIKey
- IFDGMRMUJYGWQQ-UHFFFAOYSA-N
- Catalogue number
- GC32889
- Brand
- GLPBIO
Computed properties PubChem CID 89542346 · XLogP 0.5 · TPSA 102 Ų · H-bond donors 1
- XLogP
- 0.5
- TPSA
- 102 Ų
- H-bond donors
- 1
- H-bond acceptors
- 7
- Rotatable bonds
- 4
- Heavy atoms
- 26
SMILES CC1=C(C(=O)OC2=C(C(=C(C=C12)OC)O)C=O)CC(=O)N3CCOCC3
Computed descriptors from PubChem (CID 89542346), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.
Ordering in Israel
- Lead time
- Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
- Pricing
- Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
- Documents
- Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
- Who we serve
- Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.
- Questions
- WhatsApp · +972-55-990-7576 · orders@labo.co.il