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Chemical structure of VZ185

GC65135

VZ185

Also known as (2S,4R)-N-[[2-[5-[4-[[2,6-dimethoxy-4-(2-methyl-1-oxo-2,7-naphthyridin-4-yl)phenyl]methyl]piperazin-1-yl]pentoxy]-4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl]-1-[(2S)-2-[(1-fluorocyclopropanecarbonyl)amino]-3,3-dimethylbutanoyl]-4-hydroxypyrrolidine-2-carboxamide

VZ185 is a potent, fast, and selective von Hippel-Lindau based dual degrader probe of BRD9 and BRD7 with DC50s of 4·5 and 1·8 nM, respectively· VZ185 is cytotoxic in EOL-1 and A-402 cells, with EC50s of 3 nM and 40 nM, respectively

ChemicalCAS2306193-61-1MW995.21FormulaC53H67FN8O8S
CAS number
2306193-61-1
Molecular weight
995.21
Formula
C53H67FN8O8S
Solubility
DMSO ： 200 mg/mL (200·96 mM; Need ultrasonic)
InChIKey
ZAGCLFXBHOXXEN-JPTLTNPLSA-N
Catalogue number
GC65135
Brand
GLPBIO
Computed properties PubChem CID 138454768 · XLogP 5.1 · TPSA 207 Ų · H-bond donors 3
XLogP
5.1
TPSA
207 Ų
H-bond donors
3
H-bond acceptors
14
Rotatable bonds
20
Heavy atoms
71

SMILES CC1=C(SC=N1)C2=CC(=C(C=C2)CNC(=O)[C@@H]3C[C@H](CN3C(=O)[C@H](C(C)(C)C)NC(=O)C4(CC4)F)O)OCCCCCN5CCN(CC5)CC6=C(C=C(C=C6OC)C7=CN(C(=O)C8=C7C=CN=C8)C)OC

Computed descriptors from PubChem (CID 138454768), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

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