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Chemical structure of YAP/TAZ inhibitor-2

GC65131

YAP/TAZ inhibitor-2

Also known as 2-fluoro-1-[3-[3-[4-(trifluoromethyl)phenyl]pyrazolo[5,4-b]pyridin-1-yl]azetidin-1-yl]prop-2-en-1-one

YAP/TAZ inhibitor-2 is a potent and orally active TEAD-YAP/TAZ inhibitor with an EC50 value of 3 nM· YAP/TAZ inhibitor-2 shows anti-proliferative activity· YAP/TAZ inhibitor-2 shows antitumor activity

ChemicalCAS2762617-31-0MW390.33FormulaC19H14F4N4O
CAS number
2762617-31-0
Molecular weight
390.33
Formula
C19H14F4N4O
Solubility
DMSO : 100 mg/mL (256·19 mM; Need ultrasonic)
InChIKey
GTRCXQAYBUYBBE-UHFFFAOYSA-N
Catalogue number
GC65131
Brand
GLPBIO
Computed properties PubChem CID 164885340 · XLogP 3.5 · TPSA 51 Ų · H-bond donors 0
XLogP
3.5
TPSA
51 Ų
H-bond donors
0
H-bond acceptors
7
Rotatable bonds
3
Heavy atoms
28

SMILES C=C(C(=O)N1CC(C1)N2C3=C(C=CC=N3)C(=N2)C4=CC=C(C=C4)C(F)(F)F)F

Computed descriptors from PubChem (CID 164885340), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.