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Chemical structure of GFB-12811

GC64926

GFB-12811

Also known as (1R)-1-[7-[[5-fluoro-2-(trifluoromethyl)-4-pyridinyl]amino]-1,6-naphthyridin-2-yl]-1-(1-methylpiperidin-4-yl)ethanol

GFB-12811 is a high selective and orally active CDK5 inhibitor with an IC50 of 2·3 nM

ChemicalCAS2775311-17-4MW449.44FormulaC22H23F4N5O
CAS number
2775311-17-4
Molecular weight
449.44
Formula
C22H23F4N5O
Solubility
DMSO ： 50 mg/mL (111·25 mM; Need ultrasonic)
InChIKey
GHNYLVIESIGHDJ-OAQYLSRUSA-N
Catalogue number
GC64926
Brand
GLPBIO
Computed properties PubChem CID 162439673 · XLogP 3.1 · TPSA 74.2 Ų · H-bond donors 2
XLogP
3.1
TPSA
74.2 Ų
H-bond donors
2
H-bond acceptors
10
Rotatable bonds
4
Heavy atoms
32

SMILES C[C@@](C1CCN(CC1)C)(C2=NC3=CC(=NC=C3C=C2)NC4=CC(=NC=C4F)C(F)(F)F)O

Computed descriptors from PubChem (CID 162439673), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.