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Chemical structure of GSK215

GC64888

GSK215

Also known as (2S,4R)-4-hydroxy-1-[(2S)-2-[[2-[4-[3-methoxy-4-[[4-[2-(methylcarbamoyl)anilino]-5-(trifluoromethyl)-2-pyridinyl]amino]phenyl]piperazin-1-yl]acetyl]amino]-3,3-dimethylbutanoyl]-N-[(1S)-1-[4-(4-methyl-1,3-thiazol-5-yl)phenyl]ethyl]pyrrolidine-2-carboxamide

GSK215 is a potent and selective PROTAC focal adhesion kinase (FAK) degrader with a pDC50 of 8·4· GSK215 is designed by a binder for the VHL E3 ligase and the FAK inhibitor VS-4718· GSK215 induces rapid and prolonged FAK degradation, giving a long-lasting effect on FAK levels and a marked pharmacokinetic/pharmacodynamics (PK/PD) disconnect

ChemicalCAS2743427-26-9MW985.13FormulaC50H59F3N10O6S
CAS number
2743427-26-9
Molecular weight
985.13
Formula
C50H59F3N10O6S
Solubility
DMSO ： 250 mg/mL (253·77 mM; Need ultrasonic)
InChIKey
ZGSWGXNEXAXEGV-XFCHVEHOSA-N
Catalogue number
GC64888
Brand
GLPBIO
Computed properties PubChem CID 156600270 · XLogP 7.4 · TPSA 222 Ų · H-bond donors 6
XLogP
7.4
TPSA
222 Ų
H-bond donors
6
H-bond acceptors
16
Rotatable bonds
16
Heavy atoms
70

SMILES CC1=C(SC=N1)C2=CC=C(C=C2)[C@H](C)NC(=O)[C@@H]3C[C@H](CN3C(=O)[C@H](C(C)(C)C)NC(=O)CN4CCN(CC4)C5=CC(=C(C=C5)NC6=NC=C(C(=C6)NC7=CC=CC=C7C(=O)NC)C(F)(F)F)OC)O

Computed descriptors from PubChem (CID 156600270), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

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Documents
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