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Chemical structure of GSK2126458

GC15072

GSK2126458

Also known as 2,4-difluoro-N-[2-methoxy-5-(4-pyridazin-4-ylquinolin-6-yl)-3-pyridinyl]benzenesulfonamide

GSK2126458 (GSK2126458) is an orally active and highly selective inhibitor of PI3K with Kis of 0·019 nM/0·13 nM/0·024 nM/0·06 nM and 0·18 nM/0·3 nM for p110α/β/δ/γ, mTORC1/2, respectively· GSK2126458 has anti-cancer activity

ChemicalCAS1086062-66-9MW505.5FormulaC25H17F2N5O3S
CAS number
1086062-66-9
Molecular weight
505.5
Formula
C25H17F2N5O3S
Solubility
≥ 25·3mg/mL in DMSO
InChIKey
CGBJSGAELGCMKE-UHFFFAOYSA-N
Catalogue number
GC15072
Brand
GLPBIO
Computed properties PubChem CID 25167777 · XLogP 3.3 · TPSA 115 Ų · H-bond donors 1
XLogP
3.3
TPSA
115 Ų
H-bond donors
1
H-bond acceptors
10
Rotatable bonds
6
Heavy atoms
36

SMILES COC1=C(C=C(C=N1)C2=CC3=C(C=CN=C3C=C2)C4=CN=NC=C4)NS(=O)(=O)C5=C(C=C(C=C5)F)F

Computed descriptors from PubChem (CID 25167777), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.