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Chemical structure of CC-99282

GC64851

CC-99282

Also known as 2-[(3S)-2,6-dioxopiperidin-3-yl]-4-[[2-fluoro-4-[(3-morpholin-4-ylazetidin-1-yl)methyl]phenyl]methylamino]isoindole-1,3-dione

CC-99282 is a potent and orally active cereblon (CRBN) E3 ligase modulator (CELMoD)· CC-99282 co-opts CRBN to induce potent and targeted degradation of Ikaros and Aiolos· CC-99282 can be used for researching non-Hodgkin lymphomas

ChemicalCAS2379572-34-4MW535.57FormulaC28H30FN5O5
CAS number
2379572-34-4
Molecular weight
535.57
Formula
C28H30FN5O5
InChIKey
NZYDBVQXOGPDDU-QHCPKHFHSA-N
Catalogue number
GC64851
Brand
GLPBIO
Computed properties PubChem CID 146195299 · XLogP 1.6 · TPSA 111 Ų · H-bond donors 2
XLogP
1.6
TPSA
111 Ų
H-bond donors
2
H-bond acceptors
9
Rotatable bonds
7
Heavy atoms
39

SMILES C1CC(=O)NC(=O)[C@H]1N2C(=O)C3=C(C2=O)C(=CC=C3)NCC4=C(C=C(C=C4)CN5CC(C5)N6CCOCC6)F

Computed descriptors from PubChem (CID 146195299), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

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