GC63441
CC-99677
Also known as (15R)-5-[2-chloro-5-(ethoxymethyl)pyrimidin-4-yl]oxy-15-methyl-11-thia-6,14,17-triazatetracyclo[8.8.0.02,7.012,18]octadeca-1(10),2(7),3,5,8,12(18)-hexaen-13-one
CC-99677 is a potent, covalent, and irreversible inhibitor of the mitogen-activated protein (MAP) kinase-activated protein kinase-2 (MK2) pathway in both biochemical (IC50=156·3 nM) and cell based assays (EC50=89 nM)
ChemicalCAS1887069-10-4MW469.94FormulaC22H20ClN5O3S
- CAS number
- 1887069-10-4
- Molecular weight
- 469.94
- Formula
- C22H20ClN5O3S
- Solubility
- DMSO ： 37·5 mg/mL (79·80 mM; ultrasonic and warming and heat to 60°C)
- InChIKey
- PYOQIOLRFIRRSO-LLVKDONJSA-N
- Catalogue number
- GC63441
- Brand
- GLPBIO
Computed properties PubChem CID 118936948 · XLogP 4.5 · TPSA 127 Ų · H-bond donors 2
- XLogP
- 4.5
- TPSA
- 127 Ų
- H-bond donors
- 2
- H-bond acceptors
- 8
- Rotatable bonds
- 5
- Heavy atoms
- 32
SMILES CCOCC1=CN=C(N=C1OC2=NC3=C(C=C2)C4=C(C=C3)SC5=C4NC[C@H](NC5=O)C)Cl
Computed descriptors from PubChem (CID 118936948), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.
Ordering in Israel
- Lead time
- Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
- Pricing
- Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
- Documents
- Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
- Who we serve
- Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.
- Questions
- WhatsApp · +972-55-990-7576 · orders@labo.co.il