GC64784
GGTI-286 hydrochloride
Also known as methyl (2S)-2-[[4-[[(2R)-2-amino-3-sulfanylpropyl]amino]-2-phenylbenzoyl]amino]-4-methylpentanoate;hydrochloride
GGTI-286 hydrochloride, a potent GGTase I inhibitor, is 25-fold more potent (IC50=2 μM) than the corresponding methyl ester of FTI-276· GGTI-286 hydrochloride selectively inhibits geranylgeranylation of Rap1A over farnesylation of H-Ras in NIH3T3 cells (IC50s =2 and >30 μM, respectively)· GGTI-286 hydrochloride also potently inhibits oncogenic K-Ras4B stimulation with an IC50 of 1 μM
- CAS number
- 181141-66-2
- Molecular weight
- 466.04
- Formula
- C23H32ClN3O3S
- InChIKey
- PNQLWUKJYIPIMS-JKSHRDEXSA-N
- Catalogue number
- GC64784
- Brand
- GLPBIO
Computed properties PubChem CID 86754589 · TPSA 94.5 Ų · H-bond donors 5 · H-bond acceptors 6
- TPSA
- 94.5 Ų
- H-bond donors
- 5
- H-bond acceptors
- 6
- Rotatable bonds
- 11
- Heavy atoms
- 31
SMILES CC(C)C[C@@H](C(=O)OC)NC(=O)C1=C(C=C(C=C1)NC[C@H](CS)N)C2=CC=CC=C2.Cl
Computed descriptors from PubChem (CID 86754589), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.
Ordering in Israel
- Lead time
- Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
- Pricing
- Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
- Documents
- Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
- Who we serve
- Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.
- Questions
- WhatsApp · +972-55-990-7576 · orders@labo.co.il