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Chemical structure of SJ10542

GC64464

SJ10542

Also known as 4-[[4-[1-[3-(cyanomethyl)-1-ethylsulfonylazetidin-3-yl]pyrazol-4-yl]-7H-pyrrolo[2,3-d]pyrimidin-2-yl]amino]-N-[3-[4-[4-(2,6-dioxopiperidin-3-yl)phenyl]piperazin-1-yl]propyl]benzamide

SJ10542 is a potent and selective JAK2/3 directing phenyl glutarimide (PG)-PROTAC with DC50s of 14, 11, and 24 nM for JAK2, JAK3, and JAK2-fusion ALL, respectively

ChemicalCAS2789678-92-6MW818.95FormulaC41H46N12O5S
CAS number
2789678-92-6
Molecular weight
818.95
Formula
C41H46N12O5S
Solubility
DMSO ： 46·67 mg/mL (56·99 mM; Need ultrasonic)
InChIKey
WBEBZVDAHMXWJN-UHFFFAOYSA-N
Catalogue number
GC64464
Brand
GLPBIO
Computed properties PubChem CID 162679331 · XLogP 1.8 · TPSA 223 Ų · H-bond donors 4
XLogP
1.8
TPSA
223 Ų
H-bond donors
4
H-bond acceptors
13
Rotatable bonds
14
Heavy atoms
59

SMILES CCS(=O)(=O)N1CC(C1)(CC#N)N2C=C(C=N2)C3=C4C=CNC4=NC(=N3)NC5=CC=C(C=C5)C(=O)NCCCN6CCN(CC6)C7=CC=C(C=C7)C8CCC(=O)NC8=O

Computed descriptors from PubChem (CID 162679331), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
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