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Chemical structure of SJ6986

GC62318

SJ6986

Also known as N-[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-5-yl]-2-(trifluoromethoxy)benzenesulfonamide

SJ6986 is a potent, selective and orally active GSPT1/2 degrader, with a DC50 of 2·1 nM (Dmax 99%) for GSPT1

ChemicalCAS2765625-93-0MW497.4FormulaC20H14F3N3O7S
CAS number
2765625-93-0
Molecular weight
497.4
Formula
C20H14F3N3O7S
InChIKey
RKAFYSIKAVFVPS-UHFFFAOYSA-N
Catalogue number
GC62318
Brand
GLPBIO
Computed properties PubChem CID 155925914 · XLogP 1.8 · TPSA 147 Ų · H-bond donors 2
XLogP
1.8
TPSA
147 Ų
H-bond donors
2
H-bond acceptors
11
Rotatable bonds
5
Heavy atoms
34

SMILES C1CC(=O)NC(=O)C1N2C(=O)C3=C(C2=O)C=C(C=C3)NS(=O)(=O)C4=CC=CC=C4OC(F)(F)F

Computed descriptors from PubChem (CID 155925914), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

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