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Chemical structure of VEGFR-3-IN-1

GC64205

VEGFR-3-IN-1

Also known as N-[4-chloro-3-(trifluoromethyl)phenyl]-4-[6-[4-(4-methylpiperazin-1-yl)phenyl]thieno[2,3-d]pyrimidin-4-yl]piperazine-1-carboxamide

VEGFR-3-IN-1 is a potent and selective VEGFR3 inhibitor with an IC50 of 110·4 nM· VEGFR-3-IN-1 significantly inhibits proliferation and migration of VEGF-C-induced human dermal lymphatic endothelial cells (HDLEC), MDA-MB-231, and MDA-MB-436 cells by inactivating the VEGFR3 signaling pathway, and also effectively inhibits breast cancer growth

ChemicalCAS2756668-73-0MW616.1FormulaC29H29ClF3N7OS
CAS number
2756668-73-0
Molecular weight
616.1
Formula
C29H29ClF3N7OS
InChIKey
ZYZUOYYVHYGMDE-UHFFFAOYSA-N
Catalogue number
GC64205
Brand
GLPBIO
Computed properties PubChem CID 156587562 · XLogP 5.8 · TPSA 96.1 Ų · H-bond donors 1
XLogP
5.8
TPSA
96.1 Ų
H-bond donors
1
H-bond acceptors
10
Rotatable bonds
4
Heavy atoms
42

SMILES CN1CCN(CC1)C2=CC=C(C=C2)C3=CC4=C(N=CN=C4S3)N5CCN(CC5)C(=O)NC6=CC(=C(C=C6)Cl)C(F)(F)F

Computed descriptors from PubChem (CID 156587562), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
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Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.