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Chemical structure of VEGFR Tyrosine Kinase Inhibitor II

GC16062

VEGFR Tyrosine Kinase Inhibitor II

Also known as N-(4-chlorophenyl)-2-(pyridin-4-ylmethylamino)benzamide

VEGFR Tyrosine Kinase Inhibitor II (compound 3) is a potent angiogenesis inhibitor with IC50s of 0·02, 0·18, 0·24 7·3, and 7 μM for KDR, Flt-1, c-Kit, EGF-R, and c-Src, respectively

ChemicalCAS269390-69-4MW337.8FormulaC19H16ClN3O
CAS number
269390-69-4
Molecular weight
337.8
Formula
C19H16ClN3O
Solubility
≤25mg/ml in ethanol;50mg/ml in DMSO;50mg/ml in dimethyl formamide
InChIKey
GGPZCOONYBPZEW-UHFFFAOYSA-N
Catalogue number
GC16062
Brand
GLPBIO
Computed properties PubChem CID 9797919 · XLogP 4.3 · TPSA 54 Ų · H-bond donors 2
XLogP
4.3
TPSA
54 Ų
H-bond donors
2
H-bond acceptors
3
Rotatable bonds
5
Heavy atoms
24

SMILES C1=CC=C(C(=C1)C(=O)NC2=CC=C(C=C2)Cl)NCC3=CC=NC=C3

Computed descriptors from PubChem (CID 9797919), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

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