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Chemical structure of PU139

GC63405

PU139

Also known as 2-(4-fluorophenyl)-[1,2]thiazolo[5,4-b]pyridin-3-one

PU139 is a potent pan-histone acetyltransferase (HAT) inhibitor· PU139 blocks the HATs Gcn5, p300/CBP-associated factor (PCAF), CREB (cAMP response element-binding) protein (CBP) and p300 with IC50s of 8·39, 9·74, 2·49 and 5·35 μM, respectively

ChemicalCAS158093-65-3MW246.26FormulaC12H7FN2OS
CAS number
158093-65-3
Molecular weight
246.26
Formula
C12H7FN2OS
Solubility
DMSO ： 12·5 mg/mL (50·76 mM; ultrasonic and warming and heat to 60°C)
InChIKey
QMCIVCACYJRAAY-UHFFFAOYSA-N
Catalogue number
GC63405
Brand
GLPBIO
Computed properties PubChem CID 9992116 · XLogP 2.4 · TPSA 58.5 Ų · H-bond donors 0
XLogP
2.4
TPSA
58.5 Ų
H-bond donors
0
H-bond acceptors
4
Rotatable bonds
1
Heavy atoms
17

SMILES C1=CC2=C(N=C1)SN(C2=O)C3=CC=C(C=C3)F

Computed descriptors from PubChem (CID 9992116), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

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