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Chemical structure of HPK1-IN-7

GC63006

HPK1-IN-7

Also known as 5-[[4-[[(1S)-2-hydroxy-1-phenylethyl]amino]-5-(1,3,4-oxadiazol-2-yl)pyrimidin-2-yl]amino]-3,3-dimethyl-2-benzofuran-1-one

HPK1-IN-7 is a potent, orally active HPK1 (hematopoietic progenitor kinase 1, MAP4K1) inhibitor (IC50=2·6 nM) with excellent family and kinome selectivity· HPK1-IN-7 shows selectivity against IRAK4 (59 nM) and GLK (140 nM)· HPK1-IN-7 shows robust efficacy against MC38 syngeneic tumor model in combination with anti-PD1

ChemicalCAS2320462-65-3MW458.47FormulaC24H22N6O4
CAS number
2320462-65-3
Molecular weight
458.47
Formula
C24H22N6O4
Solubility
DMSO ： 125 mg/mL (272·65 mM; Need ultrasonic)
InChIKey
RVSSNRBUPQUIEG-LJQANCHMSA-N
Catalogue number
GC63006
Brand
GLPBIO
Computed properties PubChem CID 142587219 · XLogP 2.7 · TPSA 135 Ų · H-bond donors 3
XLogP
2.7
TPSA
135 Ų
H-bond donors
3
H-bond acceptors
10
Rotatable bonds
7
Heavy atoms
34

SMILES CC1(C2=C(C=CC(=C2)NC3=NC=C(C(=N3)N[C@H](CO)C4=CC=CC=C4)C5=NN=CO5)C(=O)O1)C

Computed descriptors from PubChem (CID 142587219), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.