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Chemical structure of Pralnacasan

GC62567

Pralnacasan

Also known as (4S,7S)-N-[(2R,3S)-2-ethoxy-5-oxooxolan-3-yl]-7-(isoquinoline-1-carbonylamino)-6,10-dioxo-2,3,4,7,8,9-hexahydro-1H-pyridazino[1,2-a]diazepine-4-carboxamide

Pralnacasan (VX-740) is a potent, selective, non-peptide and orally active interleukin-1β converting enzyme (ICE, caspase 1) inhibitor with a Ki of 1·4 nM

ChemicalCAS192755-52-5MW523.54FormulaC26H29N5O7
CAS number
192755-52-5
Molecular weight
523.54
Formula
C26H29N5O7
Solubility
DMSO ： 220 mg/mL (420·22 mM; Need ultrasonic)
InChIKey
CXAGHAZMQSCAKJ-WAHHBDPQSA-N
Catalogue number
GC62567
Brand
GLPBIO
Computed properties PubChem CID 153270 · XLogP 0.9 · TPSA 147 Ų · H-bond donors 2
XLogP
0.9
TPSA
147 Ų
H-bond donors
2
H-bond acceptors
8
Rotatable bonds
6
Heavy atoms
38

SMILES CCO[C@H]1[C@H](CC(=O)O1)NC(=O)[C@@H]2CCCN3N2C(=O)[C@H](CCC3=O)NC(=O)C4=NC=CC5=CC=CC=C54

Computed descriptors from PubChem (CID 153270), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.