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Chemical structure of PI3Kα-IN-4

GC62521

PI3Kα-IN-4

Also known as (2R)-3-[6-[5-[(2-chloro-4-fluorophenyl)sulfonylamino]-6-methoxy-3-pyridinyl]-4-oxoquinazolin-3-yl]-N,2-dimethylpropanamide

PI3Kα-IN-4 is a potent, selective and orally active inhibitor of PI3Kα, with an IC50 of 1·8 nM· PI3Kα-IN-4 has antitumor activity

ChemicalCAS2322293-83-2MW560FormulaC25H23ClFN5O5S
CAS number
2322293-83-2
Molecular weight
560
Formula
C25H23ClFN5O5S
Solubility
DMSO ： 100 mg/mL (178·57 mM; Need ultrasonic)
InChIKey
LPATWVFSBNDSHR-CQSZACIVSA-N
Catalogue number
GC62521
Brand
GLPBIO
Computed properties PubChem CID 154573770 · XLogP 2.8 · TPSA 138 Ų · H-bond donors 2
XLogP
2.8
TPSA
138 Ų
H-bond donors
2
H-bond acceptors
9
Rotatable bonds
8
Heavy atoms
38

SMILES C[C@H](CN1C=NC2=C(C1=O)C=C(C=C2)C3=CC(=C(N=C3)OC)NS(=O)(=O)C4=C(C=C(C=C4)F)Cl)C(=O)NC

Computed descriptors from PubChem (CID 154573770), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.