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Chemical structure of PI3Kδ-IN-2

GC31751

PI3Kδ-IN-2

Also known as N-[5-[6-fluoro-8-[[4-(2-hydroxypropan-2-yl)piperidin-1-yl]methyl]-2-morpholin-4-ylquinazolin-4-yl]-2-methoxy-3-pyridinyl]methanesulfonamide

PI3Kδ-IN-2 (YY-20394) is a potent, orally bioavailable and selective inhibitor of PI3Kδ extracted from patent WO 2015055071 A1, compound 10; has an IC50 of 6·4 nM

ChemicalCAS1702816-75-8MW588.69FormulaC28H37FN6O5S
CAS number
1702816-75-8
Molecular weight
588.69
Formula
C28H37FN6O5S
Solubility
DMSO ： 25 mg/mL (42·47 mM)
InChIKey
NVWKNQGHVMMAJW-UHFFFAOYSA-N
Catalogue number
GC31751
Brand
GLPBIO
Computed properties PubChem CID 91754520 · XLogP 2.1 · TPSA 138 Ų · H-bond donors 2
XLogP
2.1
TPSA
138 Ų
H-bond donors
2
H-bond acceptors
12
Rotatable bonds
8
Heavy atoms
41

SMILES CC(C)(C1CCN(CC1)CC2=C3C(=CC(=C2)F)C(=NC(=N3)N4CCOCC4)C5=CC(=C(N=C5)OC)NS(=O)(=O)C)O

Computed descriptors from PubChem (CID 91754520), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
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Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
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Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.