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Chemical structure of XL177A

GC62517

XL177A

Also known as N-[(4S)-4-benzyl-5-[4-hydroxy-4-[[7-[3-(4-methylpiperazin-1-yl)propanoylamino]-4-oxoquinazolin-3-yl]methyl]piperidin-1-yl]-5-oxopentyl]-9-chloro-5,6,7,8-tetrahydroacridine-3-carboxamide

XL177A is a highly potent and selective irreversible USP7 inhibitor with an IC50 of 0·34?nM· XL177A elicits cancer cell killing through a p53-dependent mechanism

ChemicalCAS2417089-74-6MW861.47FormulaC48H57ClN8O5
CAS number
2417089-74-6
Molecular weight
861.47
Formula
C48H57ClN8O5
Solubility
DMSO ： 50 mg/mL (58·04 mM; Need ultrasonic)
InChIKey
UYJWYMWIVMCGQZ-DHUJRADRSA-N
Catalogue number
GC62517
Brand
GLPBIO
Computed properties PubChem CID 153002269 · XLogP 4.8 · TPSA 151 Ų · H-bond donors 3
XLogP
4.8
TPSA
151 Ų
H-bond donors
3
H-bond acceptors
9
Rotatable bonds
14
Heavy atoms
62

SMILES CN1CCN(CC1)CCC(=O)NC2=CC3=C(C=C2)C(=O)N(C=N3)CC4(CCN(CC4)C(=O)[C@@H](CCCNC(=O)C5=CC6=C(C=C5)C(=C7CCCCC7=N6)Cl)CC8=CC=CC=C8)O

Computed descriptors from PubChem (CID 153002269), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.