GC62482
TAS-119
Also known as 1-(2,3-dichlorobenzoyl)-4-[[5-fluoro-6-[(5-methyl-1H-pyrazol-3-yl)amino]-2-pyridinyl]methyl]piperidine-4-carboxylic acid
TAS-119 is a potent, selective and orally active Aurora A inhibitor with an IC50 of 1·0 nM· TAS-119 shows high selectivity for Aurora A over other protein kinases, including Aurora B (IC50 of 95 nM)· TAS-119 has potent antitumor activites
ChemicalCAS1453099-83-6MW506.36FormulaC23H22Cl2FN5O3
- CAS number
- 1453099-83-6
- Molecular weight
- 506.36
- Formula
- C23H22Cl2FN5O3
- Solubility
- DMSO ： 50 mg/mL (98·74 mM; Need ultrasonic)
- InChIKey
- PLAVWQHGBMTMFR-UHFFFAOYSA-N
- Catalogue number
- GC62482
- Brand
- GLPBIO
Computed properties PubChem CID 71696703 · XLogP 4.4 · TPSA 111 Ų · H-bond donors 3
- XLogP
- 4.4
- TPSA
- 111 Ų
- H-bond donors
- 3
- H-bond acceptors
- 7
- Rotatable bonds
- 6
- Heavy atoms
- 34
SMILES CC1=CC(=NN1)NC2=C(C=CC(=N2)CC3(CCN(CC3)C(=O)C4=C(C(=CC=C4)Cl)Cl)C(=O)O)F
Computed descriptors from PubChem (CID 71696703), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.
Ordering in Israel
- Lead time
- Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
- Pricing
- Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
- Documents
- Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
- Who we serve
- Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.
- Questions
- WhatsApp · +972-55-990-7576 · orders@labo.co.il