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Chemical structure of TAS-115

GC33173

TAS-115

Also known as 4-[2-fluoro-4-[(2-phenylacetyl)carbamothioylamino]phenoxy]-7-methoxy-N-methylquinoline-6-carboxamide

TAS-115 (TAS-115) is a potent VEGFR and hepatocyte growth factor receptor (c-Met/HGFR)-targeted kinase inhibitor with IC50s of 30 and 32 nM for rVEGFR2 and rMET, respectively

ChemicalCAS1190836-34-0MW518.56FormulaC27H23FN4O4S
CAS number
1190836-34-0
Molecular weight
518.56
Formula
C27H23FN4O4S
Solubility
Soluble in DMSO
InChIKey
ORRNXRYWGDUDOG-UHFFFAOYSA-N
Catalogue number
GC33173
Brand
GLPBIO
Computed properties PubChem CID 44247727 · XLogP 4.6 · TPSA 134 Ų · H-bond donors 3
XLogP
4.6
TPSA
134 Ų
H-bond donors
3
H-bond acceptors
7
Rotatable bonds
7
Heavy atoms
37

SMILES CNC(=O)C1=CC2=C(C=CN=C2C=C1OC)OC3=C(C=C(C=C3)NC(=S)NC(=O)CC4=CC=CC=C4)F

Computed descriptors from PubChem (CID 44247727), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

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Documents
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