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Chemical structure of AG-270

GC62413

AG-270

Also known as 3-(cyclohexen-1-yl)-6-(4-methoxyphenyl)-2-phenyl-5-(pyridin-2-ylamino)-1H-pyrazolo[1,5-a]pyrimidin-7-one

AG-270 is an allosteric, noncompetitive, first-in-class, reversible and orally active MAT2A inhibitor, with an IC50 of 14 nM

ChemicalCAS2201056-66-6MW489.57FormulaC30H27N5O2
CAS number
2201056-66-6
Molecular weight
489.57
Formula
C30H27N5O2
Solubility
DMSO ： 170 mg/mL (347·24 mM; Need ultrasonic)
InChIKey
LSOYYWKBUKXUHQ-UHFFFAOYSA-N
Catalogue number
GC62413
Brand
GLPBIO
Computed properties PubChem CID 134307820 · XLogP 5.6 · TPSA 78.9 Ų · H-bond donors 2
XLogP
5.6
TPSA
78.9 Ų
H-bond donors
2
H-bond acceptors
6
Rotatable bonds
6
Heavy atoms
37

SMILES COC1=CC=C(C=C1)C2=C(N=C3C(=C(NN3C2=O)C4=CC=CC=C4)C5=CCCCC5)NC6=CC=CC=N6

Computed descriptors from PubChem (CID 134307820), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
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Documents
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