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Chemical structure of AG-490 (Tyrphostin B42)

GC13854

AG-490 (Tyrphostin B42)

Also known as (E)-N-benzyl-2-cyano-3-(3,4-dihydroxyphenyl)prop-2-enamide

AG-490 (Tyrphostin B42) is EGFR inhibitor with IC50 of 0·1 μM, AG-490 also has an inhibitory effect on JAK2

ChemicalCAS133550-30-8MW294.3FormulaC17H14N2O3
CAS number
133550-30-8
Molecular weight
294.3
Formula
C17H14N2O3
Solubility
≥60mg/mL in DMSO
InChIKey
TUCIOBMMDDOEMM-RIYZIHGNSA-N
Catalogue number
GC13854
Brand
GLPBIO
Computed properties PubChem CID 5328779 · XLogP 2.4 · TPSA 93.4 Ų · H-bond donors 3
XLogP
2.4
TPSA
93.4 Ų
H-bond donors
3
H-bond acceptors
4
Rotatable bonds
4
Heavy atoms
22

SMILES C1=CC=C(C=C1)CNC(=O)/C(=C/C2=CC(=C(C=C2)O)O)/C#N

Computed descriptors from PubChem (CID 5328779), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
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Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
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Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.