GC62260
TPX-0131
Also known as (18S)-18-(difluoromethyl)-13-fluoro-7,7-dimethyl-9,20-dioxa-1,2,6,17,23-pentazapentacyclo[19.3.1.04,24.010,15.017,22]pentacosa-2,4(24),10(15),11,13,21(25),22-heptaen-5-one
TPX-0131 is a potent, selective, CNS-penetrant and orally active inhibitor of wild-type ALK (IC50 of 1·4 nM) and ALK-resistant mutation, e·g· G1202R (IC50 of 0·3 nM), L1196M (IC50 of 0·3 nM)· TPX-0131 has strong antitumor activities
ChemicalCAS2648641-36-3MW447.41FormulaC21H20F3N5O3
- CAS number
- 2648641-36-3
- Molecular weight
- 447.41
- Formula
- C21H20F3N5O3
- InChIKey
- ILAMRXVQSGVCJX-AWEZNQCLSA-N
- Catalogue number
- GC62260
- Brand
- GLPBIO
Computed properties PubChem CID 156024486 · XLogP 2.7 · TPSA 81 Ų · H-bond donors 1
- XLogP
- 2.7
- TPSA
- 81 Ų
- H-bond donors
- 1
- H-bond acceptors
- 9
- Rotatable bonds
- 1
- Heavy atoms
- 32
SMILES CC1(COC2=C(CN3[C@@H](COC4=CN5C(=C(C=N5)C(=O)N1)N=C43)C(F)F)C=C(C=C2)F)C
Computed descriptors from PubChem (CID 156024486), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.
Ordering in Israel
- Lead time
- Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
- Pricing
- Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
- Documents
- Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
- Who we serve
- Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.
- Questions
- WhatsApp · +972-55-990-7576 · orders@labo.co.il