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Chemical structure of dCBP-1

GC62211

dCBP-1

Also known as 3-[7-(difluoromethyl)-6-(1-methylpyrazol-4-yl)-3,4-dihydro-2H-quinolin-1-yl]-1-[1-[3-[2-[2-[2-[2-[[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-5-yl]amino]ethoxy]ethoxy]ethoxy]ethoxy]propanoyl]piperidin-4-yl]-N-methyl-6,7-dihydro-4H-pyrazolo[4,3-c]pyridine-5-carboxamide

dCBP-1 is a potent and selective heterobifunctional degrader of p300/CBP based on Cereblon ligand· dCBP-1 is exceptionally potent at killing multiple myeloma cells and ablates oncogenic enhancer activity driving MYC expression

ChemicalCAS2484739-25-3MW1028.11FormulaC51H63F2N11O10
CAS number
2484739-25-3
Molecular weight
1028.11
Formula
C51H63F2N11O10
Solubility
DMSO ： 50 mg/mL (48·63 mM; ultrasonic and warming and heat to 80°C)
InChIKey
ILVRLRGBSSFKIE-UHFFFAOYSA-N
Catalogue number
GC62211
Brand
GLPBIO
Computed properties PubChem CID 154690309 · XLogP 1.6 · TPSA 224 Ų · H-bond donors 3
XLogP
1.6
TPSA
224 Ų
H-bond donors
3
H-bond acceptors
16
Rotatable bonds
21
Heavy atoms
74

SMILES CNC(=O)N1CCC2=C(C1)C(=NN2C3CCN(CC3)C(=O)CCOCCOCCOCCOCCNC4=CC5=C(C=C4)C(=O)N(C5=O)C6CCC(=O)NC6=O)N7CCCC8=CC(=C(C=C87)C(F)F)C9=CN(N=C9)C

Computed descriptors from PubChem (CID 154690309), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
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Pricing
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Documents
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Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.