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Chemical structure of dCeMM2

GB40171

dCeMM2

Also known as N-(5-chloro-2-pyridinyl)-2-(5H-[1,2,4]triazino[5,6-b]indol-3-ylsulfanyl)acetamide

dCeMM2 induces ubiquitination and degradation of cyclin K by prompting an interaction of CDK12:cyclin K with a CRL4B ligase complex· The pronounced destabilization of cyclin K by dCeMM2 occurred alongside a milder destabilization of both associated kinases CDK12 and CDK13

ChemicalCAS296771-07-8MW370.82FormulaC16H11ClN6OS
CAS number
296771-07-8
Molecular weight
370.82
Formula
C16H11ClN6OS
InChIKey
VFWVTIHYVUKNGR-UHFFFAOYSA-N
Catalogue number
GB40171
Brand
GLPBIO
Computed properties PubChem CID 5286209 · XLogP 2.7 · TPSA 122 Ų · H-bond donors 2
XLogP
2.7
TPSA
122 Ų
H-bond donors
2
H-bond acceptors
6
Rotatable bonds
4
Heavy atoms
25

SMILES C1=CC=C2C(=C1)C3=C(N2)N=C(N=N3)SCC(=O)NC4=NC=C(C=C4)Cl

Computed descriptors from PubChem (CID 5286209), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

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