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Chemical structure of dBRD4-BD1

GC73356

dBRD4-BD1

Also known as 2-[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]oxy-N-[2-[2-[2-[4-[5-[2-(2-methyl-5-propan-2-ylphenoxy)pyrimidin-4-yl]-4-[4-(trifluoromethyl)phenyl]imidazol-1-yl]piperidin-1-yl]ethoxy]ethoxy]ethyl]acetamide

dBRD4-BD1 is a selective and durable BRD4 degrader with an DC50 value of 280 nM (Dmax=77%)· dBRD4-BD1 upregulates BRD2/3 protein level and shows low cytotoxicity than iBRD4-BD1

ChemicalCAS2839318-19-1MW967FormulaC50H53F3N8O9
CAS number
2839318-19-1
Molecular weight
967
Formula
C50H53F3N8O9
Solubility
DMSO ： 100 mg/mL (103·41 mM; Need ultrasonic)
InChIKey
JNAQDGFRVGMPDL-UHFFFAOYSA-N
Catalogue number
GC73356
Brand
GLPBIO
Computed properties PubChem CID 165437254 · XLogP 5.3 · TPSA 196 Ų · H-bond donors 2
XLogP
5.3
TPSA
196 Ų
H-bond donors
2
H-bond acceptors
16
Rotatable bonds
19
Heavy atoms
70

SMILES CC1=C(C=C(C=C1)C(C)C)OC2=NC=CC(=N2)C3=C(N=CN3C4CCN(CC4)CCOCCOCCNC(=O)COC5=CC=CC6=C5C(=O)N(C6=O)C7CCC(=O)NC7=O)C8=CC=C(C=C8)C(F)(F)F

Computed descriptors from PubChem (CID 165437254), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
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Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.